Sophia is a common female name derived from the Greek word for "wisdom." It may also refer to:

;Spiritual

• Sophia (wisdom), the Greek word for "wisdom", a theological concept in Hellenistic religions
• Pistis Sophia, gnostic text
• In the Ben Sirach, wisdom from the Torah.

;Music

• Sophia's Revenge (Rock Band)
• Sophia (indie rock band)
• Sophia (rock band), a Japanese band
• Sophia, a martial industrial band
• Sophia (EP) by The Crüxshadows
• Sophia (song) by Nerina Pallot
• A track on the Good Shoes album Think Before You Speak

;Buildings

• Hagia Sophia or Saint Sophia, Istanbul
• Sophia Cathedral in Russia
• Sophia University in Tokyo

;Geographic locations

• Sophia Antipolis, France
• Sophia, West Virginia

;Science

• Stratospheric Observatory for Infrared Astronomy
• 251 Sophia, asteroid

;Other

• SOPHIA (European Foundation for the Advancement of Doing Philosophy with Children)
• Sophia (vehicle) from the Blaster Master video-game series
• Sophia, a brand of Bulgarian red wine
• Sophia,Haddad in Whitley Bay high school amazing and talented also reffered to in biblical times as Envirogirl